COLLABORATORY OF AIDS RESEARCHERS FOR ERADICATION (CARE) PUBLICATIONS

Last Updated: July 27 2017

 

PUBLISHED

Ferrari G, Pollara J, Tomaras G, Haynes B.  Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection.  JID 2017:215 (Suppl 3) S152-S159 PMCID: PMC5410976  

https://www.ncbi.nlm.nih.gov/pubmed/28520963

 

Honeycutt JB, Thayer WO, Baker CE, Ribeiro RM, Lada SM, Cao Y, Cleary RA, Hudgens MG, Richman DD, Garcia JV. HIV Persistence in tissue macrophages of humanized mice during ART. Nat Med 2017 23(5):  638-643.  PMID: 28414330 PMCID: PMC5419854

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419854

 

Margolis DM, Archin NM. Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents. JID 2017:215 (Suppl 3) S111-S118. PMID: 28520964 PMCID: PMC5410986

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410986

 

Lee et al. Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID in a Viral Outgrowth Assay. JAIDS 2017 PMID:27683060  PMCID:PMC5233602.  NIHMS817501

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233602

 

Yek C, Massanella M, Peling T, Lednovich K, Nair SV, Worlock  A, Vargas M, Gianella S, Ellis RJ, Strain MC, Busch MP, Nugent CT, Richman DD.  Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types, JCM 2017 55(8):  2544-2553.

Martins LJ, Bonczkowski P, Spivak AM, De Spiegelaere W, Novis CL, DePaula-Silva AB, Malatinkova E, Typsteen W, Bosque A, Vanderkerckhove L, Planelles VModeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus. AIDS Res Hum Retroviruses. 2015 Jul 14.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/26171776

 

Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Aug 7.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/26258524

 

Spivak AM, Bosque A, Balch AH, Smyth D, Martins L, Planelles V. Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4+ T Cells from Aviremic Patients. Antimicrob Agents Chemother. 2015 Jul 13. pii: AAC.01077-15.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/26169416

 

Sung JA, Lam S, Garrido C, Archin N, Rooney CM, Bollard CM, Margolis DM. Expanded Cytotoxic T-Cell Lymphocytes Target the Latent HIV Reservoir. J Infect Dis. 2015 Jul 15;212(2):258-63.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25589335

 

Sung JA, Pickeral J, Liu L, Stanfield-Oakley SA, Lam CYK, Garrido C, Pollara J, LaBranche C, Bonsignori M, Moody MA, Yang Y, Parks R, Archin N, Allard B, Kirchherr J, Kuruc JD, Gay CL, Cohen MS, Ochsenbauer C, Soderberg K, Liao HX, Montefiori D, Moore P, Johnson S, Koenig S, Haynes BF, Nordstrom JL, Margolis DM, Ferrari G. Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/26413868

 

Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerman LR, Pilcher C, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK. Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS 2015; 29(4):411-20.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25602681

 

Ananworanich J, Dubé K, Chomont N. How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs? Curr Opin HIV/AIDS 2015 Jan;10(1):18-28. doi: 10.1097/COH.0000000000000122.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25415421

 

Archin NM, Sung JM, Garrido C, Soriano-Serabia N, Margolis DM. Eradicating HIV-1 infection: seeking to clear a persistent pathogen. Nat Rev Microbiol. 2014 Nov;12(11):750-64. doi: 10.1038/nrmicro3352.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25402363

 

Bonczkowski P, Spiegelaere WD, Bosque A, White C, Nuffel AV, Malatinkova E, Kiselinova M, Trypsteen W, Witkowski W, Vermeire J, Verhasselt B, Martins L, Woelk C, Planelles V, Vandekerckhove L. Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs. Retrovirology 2014, 11: 70. doi:10.1186/s12977-014-0070-3.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25142072

 

Bruner KM, Hosmane NN, Siliciano RFTowards an HIV-1 cure: measuring the latent reservoir. Trends Microbiol. 2015 Apr;23(4):192-203

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25747663

 

Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou H, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling proteins shell-lipophilic core nanoparticles for drug delivery. ACS Nano 2014; (Web): 25 Jul 2014 DOI: 10.1021/nn5002694.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25061969

 

Chen Y, Zhang L, Estarás C, Choi SH, Moreno L Jr, Karn J, Moresco JJ, Yates JR 3rd, Jones KA. A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation. Genes Dev. 2014 Oct 15;28(20):2261-75.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25319827

 

Cockerham LR, Siliciano JR, Sinclair E, O’Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One. 2014 Oct 23;9(10):e110731.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25340755

 

Crooks, AM, Bateson R, Cope AB, Dahl NP, Griggs MK, Kuruc JD, Gay CL, Eron JJ, Margolis DM, Bosch RJ, Archin NM. Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies. J Infect Dis 2015 Apr 15. pii: jiv218. [Epub ahead of print]

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25877550

 

Dahabieh MS, Battivelli E, Verdin E. Understanding HIV latency: the road to an HIV cure. Annu Rev Med. 2015; 66:407-21.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25587657

 

Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks DG, Strowig T, Kumar P, Siliciano JD, Zalzberg SL, Flavell RA, Shan L, Siliciano RF. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 2015 Jan 15;517(7534):381-5.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25561180

 

Dubé K, Henderson GE, Margolis DM. Framing expectations in early HIV cure research. Trends in Microbiology October 2014, Vol. 22, No. 10 doi.org/10.1016/j.tim.2014.08.003.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25280965

 

Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM. Cyclin-dependent kinase 12 increases 3′ end processing of growth factor-induced c-FOS transcripts. Mol Cell Biol. 2015 Jan;35(2):468-78.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25384976

 

Fujinaga K, Luo Z, Schaufele F, Peterlin BM. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. J Biol Chem. 2015 Jan 16;290(3):1829-36.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25492871

 

Fujinaga K, Luo Z, Peterlin BM. Genetic analysis of structure and function of 7SK small nuclear ribonucleoprotein (7SK snRNP) in cells. J Biol Chem 2014, 289: 21181-90 doi: 10.1074/jbc.M114.557751.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24917669

 

Hill AL, Rosenbloom DIS, Fu F, Nowak MA, Siliciano RF. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. PNAS 2014, doi/10.1073/pnas.1406663111.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25097264

 

Hu W, Kaminski R, Yang F, Zhang Y, Cosentino L, Li F, Luo B, Alvarez-Carbonell D, Garcia-Mesa Y, Karn J, Mo X, Khalili K. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11461-6.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25049410

 

Kim M, Hosmane NN, Bullen CK, Capoferri A, Yang HC, Siliciano JD, Siliciano RF. A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence. Nat Protoc. 2014 Dec;9(12):2755-70.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25375990

 

Laird GM, Bullen K, Rosenbloom DIS, Martin AR, Hill AL, Durand CM, Siliciano JD, Siliciano RF. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. J Clin Invest. 2015 Mar 30. pii: 80142.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25822022

 

Lam S, Sung J, Cruz C, Castillo-Caro P, Ngo M, Garrido C, Kuruc J, Archin N, Rooney C, Margolis DM, Bollard C. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther. 2015 Feb;23(2):387-95.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25366030

 

Marsden MD, Zack JA. Studies of retroviral infection in humanized mice. Virology. 2015 Feb 11. pii: S0042-6822(15)00029-X.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25680625

 

Marsden MD, Zack JA. Double trouble: HIV latency and CTL escape. Cell Host Microbe. 2015 Feb 11;17(2):141-2.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25674977

 

Marsden MD, Zack JA. Neutralizing the HIV reservoir. Cell 2014 Aug 28;158(5):971-2. doi: 10.1016/j.cell.2014.08.010.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25171398

 

Martinez-Torres F, Nochi T, Wahl A, Garcia JV, Denton PW. Hypogammaglobulineria in BLT humanized mice – an animal model of primary antibody deficiency. PLoS One 2014 Oct 1;9(10):e108663.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25271886

 

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015 Apr 15. pii: jiv230.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25883388

 

Murry JP, Godoy J, Mukim A, Swann C, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JAT. Sulfonation pathway inhibitors block reactivation of latent HIV-1. Virology 2014, 471-473:1-12. doi: 10.1016/j.virol.2014.08.016.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25310595

 

Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman DD, Siberry GK, Van Dyke RB, Burchett S, Seage III GR, Luzuriaga K for the Pediatric HIV/AIDS Cohort Study. Influence of age at virologic control on peripheral blood HIV reservoir size and serostatus in perinatally infected adolescents. JAMA Pediatr 2014; Oct 6. doi: 10.1001/jamapediatrics.2014.1560.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25286283

 

Shan L, Siliciano RF. Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection. J Clin Invest. 2014 Jun;124(6):2368-71.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24837427

 

Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen ISY, Sung An D. RNA-I mediated CCR5 knockdown provides HIV-1 resistance to memory T cells in humanized BLT mice. Mol Ther Nucleic Acids 2015 Feb 17;4:e227.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25689223

 

Soriano-Sarabia N, Bateson RE, Dahl NP, Crooks AM, Kuruc JD, Margolis DM, Archin NA. The quantitation of replication-competent HIV-1 in populations of resting CD4+ T cells. J Virol 2014 doi:10.1128/JVI.01900-14.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25253353

 

Sung JA, Lam S, Garrido C, Archin N, Rooney CM, Bollard CM, Margolis DM. Expanded Cytotoxic T-cell Lymphocytes Target the Latent HIV Reservoir. J Infect Dis. 2015 Jan 13. pii: jiv022.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25589335

 

Thompson CG, Bokhart MT, Sykes C, Adamson L, Fedoriw Y, Luciw P, Muddiman DC, Kashuba AD, Rosen EP. Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs. Antimicrob Agents Chemother. 2015 Mar 2. pii: AAC.04952-14.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25733502

 

Wang C, Abdel-Mohsen M, Strain M, Lada S, Yukl S, Cockerman L, Pilcher C, Hecht F, Sinclair E, Liegler T, Richman D, Deeks S, Pillai S. Decreased HIV-1 transcription in CCR5-Delta-32 Heterozygotes on suppressive antiretroviral therapy. J Infect Dis 2014 Jun 16. pii: jiu338.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24935955

 

Abreu CM, Price SL, Shirk EN, Cunha RD, Pianowski LF, Clements JE, Tanuri A, Gama L. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One 2014; 9(5): e97257.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24827152

 

Archin NM, Bateson R, Tripathy M, Crooks AM, Yang F, Dahl NP, Kearney MF, Anderson EM, Coffin JM, Strain MC, Richman DD, Robertson KR, Kashuba AD, Bosch RJ, Hazuda DJ, Kuruc JD, Eron JJ, Margolis DM. HIV-1 expression within resting CD4 T-cells following multiple doses of Vorinostat. J Infect Dis 2014 Sep 1;210(5):728-35. doi: 10.1093/infdis/jiu155.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24620025

 

Barry JA, Robichaud G, Bokhart MT, Thompson C, Sykes C, Kashuba AD, Muddiman DC. Mapping Antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q exactive and comparison with LC-MS/MS SRM assay. J Am Soc Mass Spectrom 2014 [Epub ahead of print].

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24744212

 

Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nature Medicine 2014. doi:10.1038/nm.3489.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24658076

 

Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology 2013; 446(1-2): 283-92.

PubMed: www.ncbi.nlm.nih.gov/pubmed/24074592

 

Chaillon A, Gianella S, Massanella Luna M, Little SJ, Richman DD, Mehta SR. A case study cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in HIV infection. Virology 2014 449; 104-8.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24418543

 

Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science 2014 Jun 20;344(6190):1392-6. doi: 10.1126/science.1250220.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24903562

 

Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, Perkey K, Archin NM, Choudhary SK, Yang K, Hudgens MG, Pastan I, Haase AT, Kashuba AD, Berger EA, Margolis DM, Garcia JV. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathogens 2014; 10(1): e1003872.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24415939

 

Doitsh G, Galloway NLK, Geng X, Monroe KM, Zepeda O, Yang Z, Hunt PW, Hatano H, Sowinski S, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 2013; doi:10.1038/nature12940.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24356306

 

Duverger A, Wolschendorf F, Anderson JC, Wagner D, Bosque A, Shishido T, Jones J, Planelles V, Willey C, Cron RQ, Kutsch O. Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation. J Virol 2013 [Epub ahead of print]

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24155393

 

Geng X, Doitsh G, Yang Z, Galloway NLK, Greene WC. Efficient delivery of lentiviral vectors into resting human CD4 T cells. Gene Therapy 2014:444-9. doi: 10.1038/gt.2014.5.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24572792

 

Gianella S, Massanella M, Richman DD, Little SJ, Spina CA, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM, California Collaborative Treatment Group 592 Team. Cytomegalovirus replication in semen is associated with higher levels of proviral HIV RNA and CD4+ T cell activation during antiretroviral treatment. J Virol 2014 88(4): 7818-27.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24789781

 

Hatano H, Strain MC, Scherzer R, Baccheti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J Infect Dis 2013; 208(9): 1436-42.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23975885

 

Ho YC, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenblood DIS, Lai J, Blankson JN, Siliciano JD, Siliciano RF. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 2013; 155(3): 540-51.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24243014

 

Honeycutt JD, Sheridan PA, Matsushima GK, Garcia JV. Humanized mouse models for HIV-1 infection in the CNS. J Neurovirol 2014 Nov 4. [Epub ahead of print]

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25366661

 

Honeycutt JB, Wahl A, Archin N, Choudhary S, Margolis DM, Garcia JV. HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T- cell-only mouse (TOM) model. Retrovirology 2013; 10: 121.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24156277

 

Jadlowsky JK, Wong JY, Graham AC, Dobrowolski C, Devor RL, Adams MD, Fujinaga K, Karn J. Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat. Mol Cell Biol 2014; 34(11).

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24636995

 

Liu J, Sisk JM, Gama L, Clements JE, Witwer KW. Tristetrapolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Mol Brain 2013; 6(1): 40.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24103357

 

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson K, Price DH, Peterlin BM. Release of P-TEFb from 7SK snSNP activates HEXIM1 transcription. Journal of Biol Chem 2014; 289(14): 9918-25. doi: 10.1074/jbc.M113.539015.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24515107

 

Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, Murray D, Strain MC, Richman DC, Chun TW, Cunningham CK, Persaud DP. HIV-1 proviral reservoirs decay continuously under sustained virologic control in early-treated HIV-1 infected children. J Infect Dis 2014. 210(10):1529-38. doi: 10.1093/infdis/jiu297

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24850788

 

Marsden MD, Zack JA. HIV/AIDS eradication. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4003-10. doi: 10.1016/j.bmcl.2013.05.032.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23735743

 

Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA. HIV latency in the humanized BLT mouse. J Virol 2012;86(1):339-47. doi: 10.1128/JVI.06366-11.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/22072769

 

Massanella M, Ouchi D, Marfil S, Llibre JM, Puertas MC, Buzón MJ, Richman DD, Orna E, Stevenson M, Gatell JM, Domingo P, Negredo E, Martinez-Picado J, Clotet B, Blanco J. Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals. PLoS One. 2014 Dec 2;9(12):e114142.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25462535

 

Mbonye U, Karn J. Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology 2014; 454-55: 328-39.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24565118

 

McManamy MEM, Hakre S, Verdin EM, Margolis DM. Therapy for latent human immunodeficiency virus type 1 infection: the role of histone deacetylase inhibitors. Antiviral Chemistry and Chemotherapy 2014; 23(4): 145-9. doi: 10.3851/IMP2551.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24318952

 

Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogran NJ, Greene WC. IFI16 sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014; 343(6169):428-32.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24356113

 

Nixon CC, Vatakis DN, Reichelderfer SN, Dixit D, Kim SG, Uittenbogaart CH, Zack JA. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood 2013; 122(13):2195-204. doi: 10.1182/blood-2013-04-496950.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23886835

 

Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A. Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation. Retrovirology 2013; 10: 119.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24156240

 

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman DD, Luzuriaga K. Absence of detectable HIV-1 viremia following treatment cessation in an infant. N Engl J Med 369(19): 1828-35.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24152233

 

Ruelas CS, Greene WC. An integrated overview of HIV-1 latency. Cell 2013 Oct 24;155(3):519-29.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24243012

 

Russell JN, Clements JE, Gama L. Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells. PLoS One 2013; 8(9):e73849.doi: 10.1371/journal/pone.0073849.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24023909

 

Salgado M, Swanson MD, Pohlmeyer CW, Buckheit RW 3rd, Wu J, Archin NM, Wiliams TM, Margolis DM, Siliciano RF, Garcia JV, Blankson JN. HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice. J Virol 2014; 88(6):3340-52. doi: 10.1128/JVI.03380-13 2014 Jan 3.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24390323

 

Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF. Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells. J Antimicrob Chemther 2013. doi:10.1093/jac/dkt338.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23999005

 

Sherrill-Mix S, Lewinski MK, Famiglietti M, Bosque A, Malani N, Ocwieja KE, Berry CC, Looney D, Shan L, Agosto LM, Pace MJ, Siliciano RF, O’Doherty U, Guatelli J, Planelles V, Bushman V, Bushman FD. HIV latency and integration site placement in five cell-based models. Retrovirology 2013; 10(90). doi: 10.1186/1742-4690-10-90.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23953889

 

Siliciano JD, Siliciano RF. HIV-1 eradication strategies: design and assessment. Review. Curr Opin HIV AIDS; 8(4): 318-25.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23698561

 

Sisk JM, Witwer KW, Tarwater PM, Clements JE. SIV replication is directly downregulated by four antiviral miRNAs. Retrovirology 2013; 10(1): 95.

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23988154

 

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Wagner GA, Pacold ME, Kosakovsky Pond PL, Caballero G, Chaillon A, Rudolph AE, Morris SR, Little SJ, Richman DD, Smith DM. Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States. J Infect Dis 2014; 209(7): 1032-8.

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Katlama C, Deeks SG, Autran B, Martinez-Picado J, van Lunzen J, Rouzioux C, Miller M, Vella S, Schmitz JE, Ahlers J, Richman DD, Sekaly RP. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet 2013; 15;381(9883):2109-17. doi: 10.1016/S0140-6736(13)60104-X.

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